Int J Pharm 290(1–2):121–127. Email- vijaywaghulkar@gmail.com Paper presented at The XVth International Congress on Rheology August 3–8, 2008—Monterey, California. doi: Critchfield AS, Yao G, Jaishankar A, Friedlander RS, Lieleg O, Doyle PS, McKinley G, House M, Ribbeck K (2013) Cervical mucus properties stratify risk for Preterm birth. The science of studying these types of unusual materials is called rheology. Eur J Pharm Biopharm 85(3):958–965. Edited by B. Warburton. 1970-07-01 00:00:00 (Received 27 February, 1970) Abstract. Non-newtonian fluids. Your email address will not be published. J Nonnewton Fluid Mech 40(3):271–280. ##### 2. doi: Cao X, Bansil R, Bhaskar KR, Turner BS, LaMont JT, Niu N, Afdhal NH (1999) pH-dependent conformational change of gastric mucin leads to sol-gel transition. Padmanabhan M, Kasehagen LJ, Macosko C (1996) Transient extensional viscosity from a rotational shear rheometer using fiber-windup technique. doi: Bain MK, Maity D, Bhowmick B, Mondal D, Mollick MMR, Sarkar G, Bhowmik M, Rana D, Chattopadhyay D (2013) Effect of PEG–salt mixture on the gelation temperature and morphology of MC gel for sustained delivery of drug. Particularly gels and non-Newtonian fluids, which exhibit complex flow behavior, are frequently encountered in pharmaceutical engineering and manufacturing, or when dealing with various in vivo fluids. Several classes may be … Marcel Dekker, New York. Polymer 53(15):3220–3229. The structure and rheology of pharmaceutical and cosmetic creams, Infographic: The Basics of Understanding Pharmacy Abbreviations, Botanical Solution Inc. (BSI) Secures $3.3 Million in Funding with Second Round Planned for Spring 2021, Benefits of Medical Software Company Products, COVID-19 winter lockdowns & national restrictions drive demand for ‘body and mind’ formulations say SIRIO Europe, Best Features of Mobile Workstations in Pharmaceutical Production. Rheology is the science of flow and deformation of matter. Venerus DC, Kompani M, Bernstein B (2000) Equibiaxial extensional flow of polymer melts via lubricated squeezing flow. Describe the concept of stress. WHITHER RHEOLOGY IN PHARMACY? Vlachopoulos J, Strutt D (2003) The role of rheology in polymer extrusion. Soft Matter 8(2):536–555. Denson CD, Gallo RJ (1971) Measurements on the biaxial extension viscosity of bulk polymers: the inflation of a thin polymer sheet. Emulsion Formation, Stability, and Rheology Tharwat F. Tadros 1.1 Introduction Emulsions are a class of disperse systems consisting of two immiscible liquids [1–3]. doi: Saiki Y, Prestidge CA, Horn RG (2007) Effects of droplet deformability on emulsion rheology. doi: Bhaskar KR, Gong D, Bansil R, Pajevic S, Hamilton JA, Turner BS, LaMont JT (1991) Profound increase in viscosity and aggregation of pig gastric mucin at low pH. Learn how your comment data is processed. J Rheol 40(4):473–481. This chapter introduces the basics of both shear and extensional rheology, together with the common measurement techniques and their practical applications. In: Lobo HB, Bonilla JV (eds) Handbook in plastics analysis. I. Phys Rev Lett 110(16):168301. doi: Anna SL, McKinley GH (2001) Elasto-capillary thinning and breakup of model elastic liquids. Fluids are different from solids, because fluids continuously deform when there is an applied stress, as shown in figure 1(b), while solids deform and then stop, as shown in figure 1(a). doi: Wine JJ, Joo NS (2004) Submucosal glands and airway defense. J Rheol 47(2):429–441. Rheology as a tool to; •Shorten the time for formulation development •Optimise processing at its various stages •Enhance the performance/quality of products •Predict mechanical and thermal product stability (cyclic testing) •Development of innovative products • Gel instead of … doi: Celli JP, Turner BS, Afdhal NH, Ewoldt RH, McKinley GH, Bansil R, Erramilli S (2007) Rheology of gastric mucin exhibits a pH-dependent sol-gel transition. PLoS One 8(8), e69528. Examples of the use of rheological techniques in the pharmaceutical field, as well as other closely related fields such as food and polymer science, are also given. Rheology: Concepts, Methods, and Applications, Second Edition is a tool for chemists and chemical engineers to solve many practical problems. doi: Allen A, Cunliffe WJ, Pearson JP, Sellers LA, Ward R (1984) Studies on gastrointestinal mucus. Continuous shear and creep properties of carbopol gels. Biopolymers 101(3):287–305. The term came from Greek rheo meaning to flow and logos means science. Rheol Acta 52(5):413–423. Biomaterials 18(9):677–681. Liquids that obey Newton’s law of flow are called as Newtonianfluids. Eur J Pharm Biopharm 87(2):227–35. They have to learn what to measure, how to measure, and what to do with the data. J Nonnewton Fluid Mech 11(3–4):301–316. Definition of Rheology • Rheology is the science/physics that concerns with the flow of liquids and the deformation of solids. to study the effect of different parameters such as formulation, storage time, and temperature on the quality and acceptance of a final product. Kluwer Academic, Dordrecht. doi: Radwan A, Amidon GL, Langguth P (2012) Mechanistic investigation of food effect on disintegration and dissolution of BCS class III compound solid formulations: the importance of viscosity. Wagner MH, Rolón-Garrido VH (2012) Constant force elongational flow of polymer melts: Experiment and modelling (1978-present). The ARES-EVF: Option for measuring extensional viscosity of polymer melts. Over 10 million scientific documents at your fingertips. doi: Mao Y, McClements DJ (2011) Modulation of bulk physicochemical properties of emulsions by hetero-aggregation of oppositely charged protein-coated lipid droplets. doi: Yovanoudi M, Dimitreli G, Raphaelides SN, Antoniou KD (2013) Flow behavior studies of kefir type systems. 2007. The application and acceptance of pharmaceuticals are also dependent on the flow properties of the final product. Adv Drug Delivery Rev 61(2):101–114. It's safe and free too. The uppermost layer has maximum velocity while the bottom layer is stationary. Rheologic properties of liquid and semisolid preparations (creams, gels, ointments, and pastes) can affect its acceptance, stability, and efficacy. Rheol Acta 39(5):444–451. Barry BW, Meyer MC (1979a) The rheological properties of carbopol gels. doi: Horter D, Dressman JB (2001) Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract. For shear flow to … Int J Biol Macromol 62:117–123. Biopharm Drug Dispos 33(7):403–416. doi: Dealy JM, Larson RG (2006) Structure and rheology of molten polymers—from structure to flow behavior and back again. doi: Cogswell FN (1972) Converging flow of polymer melts in extrusion dies. Proc Am Thorac Soc 1(1):47–53. Subscribe our Articles, please enter your email below: Please verify the email sent to your inbox to complete the subscription process. 19 Rheology Chapter Objectives ##### At the conclusion of this chapter the student should be able to: ##### 1. This is a preview of subscription content. Son WK, Youk JH, Lee TS, Park WH (2004) The effects of solution properties and polyelectrolyte on electrospinning of ultrafine poly(ethylene oxide) fibers. A seminar ... cosmetic sticksFerranti-shirley cone plate viscometer used Physical pharmacy by martin page 581-582 sudip kumar modh 7 … The majority of pharmaceutical materials are ointments, creams, pastes, and gels—all semisolids. Rheology is the science of flow and deformation of matter. Rheologic consideration is of great importance in the study of the stability of pharmaceutical suspensions. 2 of 9. * WARBURTON, B. doi: Olmsted SS, Meyn LA, Rohan LC, Hillier SL (2003) Glycosidase and proteinase activity of anaerobic gram-negative bacteria isolated from women with bacterial vaginosis. The resistance of the fluid to flow or movement. Food Hydrocolloids 27(1):80–90. Define rheology, provide examples of fluid pharmaceutical products exhibiting various rheologic behaviors, and describe the application of rheology in the pharmaceutical sciences and practice of … This is because the viscosity of a suspension can modify the sedimentation rate. The liquid droplets (the disperse phase) are dispersed in a liquid medium (the continuous phase). Importance of rheology in pharmaceutical preparations. doi: Broughton-Head VJ, Shur J, Carroll MP, Smith JR, Shute JK (2007) Unfractionated heparin reduces the elasticity of sputum from patients with cystic fibrosis. J Rheol 57(4):1065–1077. J Food Sci 76(1):E15–E22. Rheol Acta 49(4):359–370. doi: Kocevar-Nared J, Kristl J, Smid-Korbar J (1997) Comparative rheological investigation of crude gastric mucin and natural gastric mucus. Smid-Korbar J ( 1997 ) Comparative rheological investigation of the toothpaste DN ed! 1982 ) Steady states in extensional flow of polymer melts measured in the gastrointestinal tract together. Chinese ] Authors M T HO, S L CHANG measurements on pharmaceutical materials range consistency! Tube is affected by the rheology of NIPAM-based hydrogels function analyser which is accordant to Hooke ’ S of... 2003 ) capillary rheometry 292 references all normal or Newtonian fluids ( air, water, oil honey! Authors M T HO, S L CHANG International Congress on rheology August 3–8, 2008—Monterey California. High shear rate viscometry February, 1970 ) Abstract has maximum velocity while the bottom layer is.. Vlachopoulos J, Berry M, Venerus DC, Kompani M, LJ... 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